Hybridization-Sensitive Fluorescent Probes for DNA and RNA by a Modular “Click” Approach
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00241
Abstract: Fluorescent DNA probes were prepared in a modular approach using the “click” post-synthetic modification strategy. The new glycol-based module and DNA building block place just two carbons between the phosphodiester bridges and anchor the dye… read more here.
Keywords: hybridization sensitive; dna; fluorescent; light effect ... See more keywords
Hybridization-sensitive Fluorescent Oligonucleotide Probe Conjugated with Cell-penetrating Peptides for Enhanced Cellular Uptake
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry Letters"
DOI: 10.1246/cl.170813
Abstract: Intracellular delivery of oligonucleotides is essential not only for antisense- and RNAi-therapeutics, but also for live-cell RNA imaging with fluorescent nucleic acid probes. Herein, we developed oligonucleotide–peptide conjugates synthesized via Cu-catalyzed alkyne-azide cycloaddition between an… read more here.
Keywords: penetrating peptides; hybridization sensitive; probe; enhanced cellular ... See more keywords