Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents
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DOI: 10.1007/s12039-017-1415-y
Abstract: Abstract Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative… read more here.
Keywords: click reaction; sulfonamide hybrids; molecular hybridization; novel sulfonamide ... See more keywords
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.
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DOI: 10.1039/c9md00200f
Abstract: Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a… read more here.
Keywords: strategy towards; trypanosoma species; towards potent; hybridization strategy ... See more keywords