Hybridized quinoline derivatives as anticancer agents: Design, Synthesis, biological evaluation and molecular docking.
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DOI: 10.2174/1871520618666181112121058
Abstract: OBJECTIVE Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. METHODS Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine… read more here.
Keywords: derivatives anticancer; anticancer agents; tubulin polymerization; hybridized quinoline ... See more keywords