Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance
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DOI: 10.1007/s00044-021-02699-5
Abstract: The widespread deaths of tuberculosis from many decades demands an urgent need for the development of novel anti-tubercular scaffolds that are more potent and highly selective with lower cytotoxicity. Isatin hybrids are endowed with an… read more here.
Keywords: novel anti; anti tubercular; hybrids novel; repositioning isatin ... See more keywords
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.01.006
Abstract: A novel series of substituted N-(2-(2,3-dioxoindolin-1-yl)acetyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide was designed, synthesized and evaluated for in vitro Reverse Transcriptase (RT) inhibitory activity. This series is a combination of peculiar structural features from leading scaffolds of [(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) and… read more here.
Keywords: isatin hybrids; hybrids novel; reverse; reverse transcriptase ... See more keywords
Benzofuran-selenadiazole hybrids as novel α-glucosidase and cyclooxygenase-2 inhibitors with antioxidant and cytotoxic properties.
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DOI: 10.1016/j.bioorg.2020.103945
Abstract: Series of 2-arylbenzofuran-1,2,3-selenodiazole hybrids were prepared via multiple reactions and then evaluated in vitro through enzymatic assay for inhibitory effect against α-glucosidase and cyclooxygenase-2 (COX-2) activities including antioxidant activity. The presence of 1,2,3-selenodiazole moiety resulted… read more here.
Keywords: selenadiazole hybrids; cyclooxygenase; hybrids novel; glucosidase cyclooxygenase ... See more keywords
Umbelliferone–oxindole hybrids as novel apoptosis inducing agents
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c7nj02578e
Abstract: In furtherance of our endeavour towards the synthesis of novel bioactive agents, a panel of (E)-3-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)indolin-2-one derivatives were synthesized using diverse 5-substituted oxindoles and 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde (3a). These synthesized analogues were further evaluated for their in… read more here.
Keywords: novel apoptosis; umbelliferone oxindole; apoptosis inducing; apoptosis ... See more keywords