Itaconic acid hybrids as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10147-6
Abstract: Abstract In this paper, we report the synthesis of novel hybrids 2–14 based on itaconic acid and fluoroaniline, pyridine, indole and quinoline scaffolds. Itaconic acid is a naturally occurring compound with a Michael acceptor moiety,… read more here.
Keywords: anticancer agents; itaconic acid; acid hybrids; hybrids potential ... See more keywords
Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02018-6
Abstract: Abstract Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain… read more here.
Keywords: nicotinonitrile coumarin; hybrids potential; acetylcholinesterase inhibitors; coumarin hybrids ... See more keywords
1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.033
Abstract: Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms, are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and community-acquired bacterial infections have already put a heavy burden on the global… read more here.
Keywords: anti bacterial; triazole quinoline; quinolone hybrids; quinoline quinolone ... See more keywords
Hydroxamic acid hybrids as the potential anticancer agents: An Overview.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112679
Abstract: Hydroxamic acid derivatives are potential histone deacetylase inhibitors, and several hydroxamic acid-based histone deacetylase inhibitors have already been used clinically as potent anticancer agents, so hydroxamic acid derivatives are useful scaffolds for the development of… read more here.
Keywords: anticancer agents; hydroxamic acid; acid hybrids; anticancer ... See more keywords
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2166036
Abstract: Abstract A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2,4-dione 4a–e, 1,3,4-thiadiazole aryl urea 6a–d, and cyanothiouracil moieties 8a–d was synthesised. The in vitro antitumor effect of the new hybrids was assessed against three cancer… read more here.
Keywords: vegfr; potential vegfr; silico; new benzothiazole ... See more keywords
Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2023-0002
Abstract: Quinolone derivatives, represented by fluoroquinolones, have emerged as the most commonly prescribed antibacterials for the treatment of various bacterial infections. In particular, the combination of a quinolone moiety with other antibacterial pharmacophores has the potential to act… read more here.
Keywords: quinolone hybrids; potential antibacterial; activity; drug resistant ... See more keywords