New Efficient Synthesis of tRNA Related Adenosines Bearing the Hydantoin Ring (ct6A, ms2ct6A) by Intramolecular Cyclization of N6‐(N‐Boc‐α‐aminoacyl)‐adenosine Derivatives
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DOI: 10.1002/cbic.202100655
Abstract: A novel and efficient way for the synthesis of N6‐hydantoin‐modified adenosines, which utilizes readily available N6‐(N‐Boc‐α‐aminoacyl)‐adenosine derivatives, was developed. The procedure is based on the epimerization‐free, Tf2O‐mediated conversion of the Boc group into an isocyanate… read more here.
Keywords: aminoacyl adenosine; adenosine derivatives; boc; hydantoin ... See more keywords
Tackling the Spiro Tetracyclic Skeleton of Cyanogramide: Incorporation of a Hydantoin Moiety.
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DOI: 10.1021/acs.orglett.8b03540
Abstract: Wang's enantioselective thiourea-catalyzed spiro-annulation paved the way to the first tetracyclic analog of the marine natural product cyanogramide from the actinobacterium Actinoalloteichus cyanogriseus. The synthesis comprises seven steps starting from an alkylidene indolinone. Installation of… read more here.
Keywords: spiro tetracyclic; skeleton cyanogramide; hydantoin; tackling spiro ... See more keywords
Synthesis of new 5-benzylidene-hydantoin esters
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DOI: 10.1177/17475198221104183
Abstract: Compounds containing a hydantoin moiety are found in several medicines in clinical use. In this research, ethyl- and methyl-[2-(5-benzylidene)-2,4-dioxoimidazolidin-3-yl]acetyl esters are successfully synthesized over four reaction steps using conventional methods. The synthesis begins by subjecting… read more here.
Keywords: benzylidene hydantoin; new benzylidene; benzylidene; hydantoin esters ... See more keywords
Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases
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DOI: 10.3390/ijms232214115
Abstract: A series of novel 1-(4-benzenesulfonamide)-3-alkyl/benzyl-hydantoin derivatives were synthesized and evaluated for the inhibition of eukaryotic and human carbonic anhydrases (CAs, EC 4.2.1.1). The prepared compounds were screened for their hCA inhibitory activities against three cytosolic… read more here.
Keywords: human carbonic; carbonic anhydrases; hydantoin; benzenesulfonamides incorporating ... See more keywords