Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C–N bonds†
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DOI: 10.1039/d0sc06188c
Abstract: Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated nitriles tethered by a urea linkage to a series of electronically unactivated heterocyclic precursors. The substitution reaction constitutes a… read more here.
Keywords: migratory insertion; bridged medium; scaffolds migratory; ring scaffolds ... See more keywords