Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105643
Abstract: As a member of Bcl-2 protein family, myeloid cell leukemia-1 (Mcl-1) plays a critical role in cell apoptosis and has become a promising anti-cancer drug target. Herein, we designed and synthesized a series of hydantoin… read more here.
Keywords: synthesis biological; hydantoin derivatives; design synthesis; biological evaluation ... See more keywords
Biologically Oriented Hybrids of Indole and Hydantoin Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020602
Abstract: Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules.… read more here.
Keywords: hybrids indole; indole hydantoin; growth; biologically oriented ... See more keywords