Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.10.007
Abstract: Androgenetic complete hydatidiform moles are human pregnancies with no embryos and affect 1 in every 1,400 pregnancies. They have mostly androgenetic monospermic genomes with all the chromosomes originating from a haploid sperm and no maternal… read more here.
Keywords: mutations mechanism; hydatidiform; androgenetic complete; complete hydatidiform ... See more keywords
Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.07.002
Abstract: INTRODUCTION Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in… read more here.
Keywords: expression; factor; growth; hydatidiform moles ... See more keywords
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2022.2118050
Abstract: ABSTRACT Introduction Hydatidiform moles (HMs) are pathologic conceptions with unique genetic bases and abnormal placental villous tissue. Overlapping ultrasonographical and histological manifestations of molar and non-molar (NM) gestations and HMs subtypes makes accurate diagnosis challenging.… read more here.
Keywords: diagnosing hydatidiform; molecular biomarkers; challenges diagnosing; moles review ... See more keywords
Loss of X Chromosome Inactivation in Androgenetic Complete Hydatidiform Moles With 46, XX Karyotype
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DOI: 10.1097/pgp.0000000000000697
Abstract: Most complete hydatidiform moles (CHMs) showcase an androgenetic nature of the nuclear genome. In the normal female embryo, one of the 2 X chromosomes is inactive. However, the status of X chromosome inactivation (XCI) in… read more here.
Keywords: expression; androgenetic chms; complete hydatidiform; normal female ... See more keywords
ABO blood type compatibility is not a risk factor for gestational trophoblastic neoplasia development from androgenetic complete hydatidiform moles
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13237
Abstract: Complete hydatidiform moles (CHMs) are allografts to patients in terms of an androgenetic origin. Thus, some immunological reactions may be involved in the development of gestational trophoblastic neoplasia (GTN) from CHMs. This study aimed to… read more here.
Keywords: abo blood; gestational trophoblastic; complete hydatidiform; hydatidiform moles ... See more keywords
Expression of Pro-Apoptotic Bax and Anti-Apoptotic Bcl-2 Proteins in Hydatidiform Moles and Placentas With Hydropic Changes
Sign Up to like & getrecommendations! Published in 2019 at "ACTA MEDICA IRANICA"
DOI: 10.18502/acta.v57i1.1750
Abstract: Abstract- Morphologic examination still forms the main diagnostic tool in the differential diagnosis of molar placentas. However the criteria are subjective and show considerable inter-observer variability among pathologists. The aim of the present study was… read more here.
Keywords: partial hydatidiform; hydropic; complete hydatidiform; hydatidiform ... See more keywords
Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis.
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DOI: 10.21873/anticanres.12329
Abstract: BACKGROUND/AIM To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles. MATERIALS AND METHODS We searched electronic databases included Medline, WOK, Cochrane Library and CNKI, through January 24, 2015. Experts were… read more here.
Keywords: partial complete; distinguishing partial; value distinguishing; hydatidiform ... See more keywords
Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles
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DOI: 10.3390/ijms20204999
Abstract: Gene expression studies of molar pregnancy have been limited to a small number of candidate loci. We analyzed high-dimensional RNA and protein data to characterize molecular features of complete hydatidiform moles (CHMs) and corresponding pathologic… read more here.
Keywords: immune pathways; complete hydatidiform; placental functions; dysregulation placental ... See more keywords
Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119656
Abstract: The general notion of complete hydatidiform moles is that most of them consist entirely of paternal DNA; hence, they do not express p57, a paternally imprinted gene. This forms the basis for the diagnosis of… read more here.
Keywords: tssc3 rb1; hydatidiform; mole; hydatidiform moles ... See more keywords