Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.101
Abstract: The enzyme Urocanate Hydratase (UH) participates in the catabolic pathway of L-histidine. Trypanosoma cruzi Urocanate Hydratase (TcUH) is identified as a therapeutic molecular target in the WHO/TDR Targets Database. We report the 3D structure determination… read more here.
Keywords: hydratase; trypanosoma cruzi; urocanate hydratase; structure ... See more keywords
Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02180-8
Abstract: The ammonia-oxidizing thaumarchaeal 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle is one of the most energy-efficient CO2 fixation cycles discovered thus far. The protein encoded by Nmar_1308 (from Nitrosopumilus maritimus SCM1) is a promiscuous enzyme that catalyzes two essential… read more here.
Keywords: crotonyl coa; dehydratase; coa; coa hydratase ... See more keywords
Fumarate Hydratase and S-(2-Succinyl)-Cysteine Immunohistochemistry Shows Evidence of Fumarate Hydratase Deficiency in 2% of Uterine Leiomyosarcomas: A Cohort Study of 348 Tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000918
Abstract: Approximately 1% to 1.5% of uterine leiomyomas are fumarate hydratase (FH)-deficient (FHd). A subset of these are associated with germline FH mutations. However, the prevalence and clinicopathologic characteristics of FHd uterine leiomyosarcoma (uLMS) remain unknown.… read more here.
Keywords: hydratase; immunohistochemistry; succinyl cysteine; fumarate hydratase ... See more keywords
Staphylococcus aureus oleate hydratase produces ligands that activate host PPARĪ±
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2024.1352810
Abstract: Commensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain to… read more here.
Keywords: ppar; host; oleate hydratase; hydratase ... See more keywords