Copper-Catalyzed Alkynylation of Hydrazides: An Easy Access to Functionalized Azadipeptides.
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DOI: 10.1021/acs.orglett.2c02625
Abstract: We report a copper-catalyzed alkynylation of azadipeptides using ethynylbenziodoxolone (EBX) reagents. Nonsymmetrical ynehydrazides could be obtained in 25-97% yield using azaglycine derivatives as nucleophiles. The transformation is compatible with most functional groups naturally occurring on… read more here.
Keywords: hydrazides easy; easy access; catalyzed alkynylation; alkynylation hydrazides ... See more keywords