Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-018-0841-x
Abstract: A new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive… read more here.
Keywords: monosubstituted hydrazone; cyclodextrin; complex formation; hydrazone ... See more keywords
Hydrazone chemistry mediated toehold strand displacement cascade and its application for 5-hydroxymethylfurfural analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.01.008
Abstract: Hydrazone chemistry has been firstly explored as capturing mode for interface supported toehold strand displacement cascade (TSDC). The method has been further established for analysis of 5-hydroxymethylfurfural (HMF) based on hydrazone chemistry-mediated TSDC. HMF containing… read more here.
Keywords: strand displacement; chemistry; hydrazone chemistry; displacement cascade ... See more keywords
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111649
Abstract: (NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. Thus, there is a need to develop inhibitors of NQO2 that… read more here.
Keywords: discovery potent; inhibitors nqo2; aminoquinoline; hydrazone ... See more keywords
Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.08.004
Abstract: &NA; Targeting protein aggregation for the therapy of neurodegenerative diseases remains elusive for medicinal chemists, despite a number of small molecules known to interfere in amyloidogenesis, particularly of amyloid beta (A&bgr;) protein. Starting from previous… read more here.
Keywords: mannich base; bgr; methoxyisatin isopropylphenyl; isopropylphenyl hydrazone ... See more keywords
Polypyridyl-hydrazone based Ruthenium(II) complexes: Spectral and computational analysis
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.01.029
Abstract: Abstract New octahedral Ruthenium(II) complexes of the general composition [Ru(bpy)2(L)]Cl containing aroyl hydrazone Schiff base ligands (L) (where bpy = bipyridine, L = 4-((E)-(furan-2-carboylimino)methyl)benzoic acid (L1), 4-((E)-(4-methoxybenzoylimino)methyl)benzoic acid (L2) and 4-((E)-(4-nitrobenzoylimino)methyl)benzoic acid (L3)) have been synthesized. All the three… read more here.
Keywords: methyl benzoic; geometry; benzoic acid; ruthenium complexes ... See more keywords
Organotin(IV) complexes derived from hydrazone Schiff base: Synthesis, crystal structure, in vitro cytotoxicity and DNA/BSA interactions
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.05.017
Abstract: Abstract Four new organotin(IV) complexes Me 2 SnL 1 , Ph 2 SnL 1 , Me 2 SnL 2 and Ph 2 SnL 2 (H 2 L 1 = 5-chlorosalicylaldehyde isonicotinoyl hydrazone and H 2 L… read more here.
Keywords: crystal structure; hydrazone schiff; dna; bsa ... See more keywords
Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.11.015
Abstract: Abstract Cu(II) phenanthroline complexes are able to cleave DNA and show cytotoxic activity against cancer cells. Also, the biological activity of hydrazone-based compounds has been reported in the literature. This motivated us to combine these… read more here.
Keywords: complexes hydrazone; functionalized phenanthrolines; self activating; hydrazone functionalized ... See more keywords
Synthesis, characterization, biological, X-ray diffraction analysis and computational chemistry studies of new 2-acetylpyridine derivative hydrazone and its Zn(II) complex
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128152
Abstract: Abstract A new aroyl hydrazone ligand ((E)-2-phenyl-N’-(1-(pyridine-2-yl)ethylidene)acetohydrazide) HL and its metal complex [ZnL2] (1) have been synthesized and characterized by using elemental analysis, IR and UV–vis spectroscopy methods. All data indicate that the ligand is… read more here.
Keywords: molecular structures; ray diffraction; diffraction analysis; analysis ... See more keywords
Synthesis, crystal growth, spectroscopic characterization, Hirshfeld surface analysis and DFT investigations of novel nonlinear optically active 4-benzoylpyridine-derived hydrazone
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130858
Abstract: Abstract Hydrazones are the vital compounds which possess remarkable properties and are widely used in organic synthesis, analytical chemistry and medicine. In this research, single crystals of a novel hydrazone, 4-(2-(furan-2-carbonyl)hydrazono(phenyl)methyl)-pyridin-1-ium ethylsulphate hydrate (FHPE), were… read more here.
Keywords: hydrazone; synthesis; surface analysis; spectroscopy ... See more keywords
Stimuli-responsive fluorescence switching: Aggregation-induced emission (AIE), protonation effect and reversible mechanofluochromism of tetraphenylethene hydrazone-based dyes
Sign Up to like & getrecommendations! Published in 2020 at "Organic Electronics"
DOI: 10.1016/j.orgel.2019.105466
Abstract: Abstract Two new simple and easily prepared TPE-based hydrazone derivatives of isoniazid (TBIH) and benzoyl hydrazide (TBBH) have been designed and synthesized, which showed AIE behavior and remarkable and reversible mechanofluorochromic (MFC) properties. The spectroscopic… read more here.
Keywords: fluorescence; responsive fluorescence; effect; stimuli responsive ... See more keywords
Substituent effects on the isomerization of hydrazone switches driven by the intramolecular hydrogen bond
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.06.022
Abstract: Abstract In this work, the substituent effects on hydrogen bonding in one kind of hydrazone-based switch are revealed. The E/Z isomerization ratios of these hydrazones and their intramolecular hydrogen bond strengths in the Z form… read more here.
Keywords: substituent effects; intramolecular hydrogen; hydrogen bond; hydrazone ... See more keywords