Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000377
Abstract: Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one‐pot, four‐component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by 1H nuclear magnetic… read more here.
Keywords: novel hydrazone; hydrazone derivatives; incorporating pyridine; log ic50 ... See more keywords
Quinoline Hydrazide/Hydrazone Derivatives: Recent Insights on Antibacterial Activity and Mechanism of Action
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200571
Abstract: Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater difficulty in the treatment of infectious diseases. Therefore, the development of new chemical entities with different mechanisms of action is essential in the… read more here.
Keywords: hydrazone derivatives; hydrazide hydrazone; quinoline hydrazide;
Unveiled understanding on corrosion inhibition mechanisms of hydrazone derivatives based on naproxen for mild steel in HCl: A joint experimental/theoretical study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114442
Abstract: Abstract The current investigation seeks to explore the adsorption mechanism of newly synthesized Naproxen-based hydrazones on mild steel (MS) surface in 1.0 M HCl solution and their corrosion inhibition efficiencies. To this end, two hydrazone derivatives… read more here.
Keywords: hydrazone derivatives; phd; mild steel; corrosion inhibition ... See more keywords
Insights into the pharmaceutical properties and in silico study of novel hydrazone derivatives
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-81555-z
Abstract: It has been established that the Hydrazone derivatives have important pharmacological effects. In the first step, hydrazine (NH2NH2) reacts with a compound containing a carbonyl group (C = O) in the presence of ethanol and heat, leading… read more here.
Keywords: hydrazone; pharmaceutical properties; hydrazone derivatives; insights pharmaceutical ... See more keywords
Anti-hepatocellular carcinoma activities of novel hydrazone derivatives via downregulation of interleukin-6
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra05854b
Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related morbidity worldwide. Sorafenib is a first-line drug for the treatment of HCC, however, it is reported to cause serious adverse effects and may lead… read more here.
Keywords: hepatocellular carcinoma; downregulation interleukin; anti hepatocellular; hydrazone derivatives ... See more keywords
Copper-catalyzed synthesis of hydrazone derivatives between oxime esters and azodicarboxylates
Sign Up to like & getrecommendations! Published in 2025 at "Organic Chemistry Frontiers"
DOI: 10.1039/d5qo00775e
Abstract: A novel copper-catalyzed reaction of oxime esters with azodicarboxylates is herein described, affording a range of unsymmetrically substituted N-acyl hydrazone derivatives with excellent E selectivity in 31-77% yields. Hydrazone derivatives... read more here.
Keywords: catalyzed synthesis; hydrazone derivatives; oxime esters; copper catalyzed ... See more keywords
Synthesis, anticancer and antimicrobial evaluation of new pyridyl and thiazolyl clubbed hydrazone scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1692870
Abstract: Abstract A series of new hydrazones bearing pyridyl and thiazolyl scaffolds have been synthesized and evaluated for their in vitro anticancer and antimicrobial activities. The anticancer activity was evaluated against the A549 lung cancer cell… read more here.
Keywords: synthesis anticancer; pyridyl thiazolyl; anticancer antimicrobial; hydrazone derivatives ... See more keywords
Cytotoxic effects, carbonic anhydrase isoenzymes, α-glycosidase and acetylcholinesterase inhibitory properties, and molecular docking studies of heteroatom-containing sulfonyl hydrazone derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1792345
Abstract: Abstract Today, interest in studies on the search for new drugs to be used in diseases such as cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as prevention of microbial inflammation is increasing day… read more here.
Keywords: carbonic anhydrase; hydrazone derivatives; heteroatom containing; sulfonyl hydrazone ... See more keywords
Design and synthesis of bis(indolyl)-hydrazide-hydrazone derivatives and their antifungal activities against plant pathogen fungi
Sign Up to like & getrecommendations! Published in 2024 at "Natural Product Research"
DOI: 10.1080/14786419.2024.2371994
Abstract: Abstract A series of bis(indolyl)-hydrazide-hydrazone derivatives were synthesised, and their structures were characterised using 1H-NMR and HRMS. The antifungal activity of the prepared compounds was evaluated against Pyricularia oryzae Cav., Colletotrichum gloeosporioides Penz., Botrytis cinerea… read more here.
Keywords: hydrazide hydrazone; hydrazone derivatives; indolyl hydrazide; bis indolyl ... See more keywords
Synthesis of hydrazone derivatives of benzofuran and their antibacterial and antifungal activity
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217090183
Abstract: A series of benzofuran hydrazones 6a–6n were synthesized from benzofuran aldehyde and substituted aromatic hydrazides 5a–5n. Structures of all compounds were confimed by IR, 1H and 13C NMR, and Mass spectral data. These compounds were… read more here.
Keywords: benzofuran antibacterial; hydrazone derivatives; derivatives benzofuran; synthesis hydrazone ... See more keywords
Synthesis and antiproliferative activity of novel 4-azasteroidal-17-hydrazone derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Research"
DOI: 10.1177/1747519819851706
Abstract: A new series of 4-azasteroidal-17-hydrazone derivatives have been synthesized from androstenedione. Their structures were characterized by analysis and spectroscopic data. The antiproliferative activity of synthesized compounds against three cancer cells (human lung adenocarcinoma, human oesophageal… read more here.
Keywords: hydrazone derivatives; activity; human gastric; antiproliferative activity ... See more keywords