Design and Synthesis of β‐Carboline Hydrazone Hybrids as New α‐Amylase and α‐Glucosidase Inhibitors: Inhibition Kinetics and Molecular Docking Studies
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DOI: 10.1002/ajoc.202500365
Abstract: Diabetes mellitus (DM) is a chronic metabolic disorder that has been flagged as a global threat with progression at an alarming rate worldwide. The dual inhibition of carbohydrate hydrolases, α‐amylase, and α‐glucosidase, has been considered… read more here.
Keywords: hybrids new; carboline hydrazone; amylase glucosidase; hydrazone hybrids ... See more keywords
Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids
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DOI: 10.1002/open.202500276
Abstract: The current study reports a convenient synthetic approach to carboxamide hydrazone hybrids 2a, b. Their chemical structures are investigated using infrared, nuclear magnetic resonance, and mass spectroscopies. In addition, the 3D structure of 2a is… read more here.
Keywords: crystallographic hirshfeld; carboxamide hydrazone; ray crystallographic; hydrazone hybrids ... See more keywords
Resveratrol/Hydrazone Hybrids: Synthesis and Chemopreventive Activity against Colorectal Cancer Cells
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DOI: 10.3390/pharmaceutics14112278
Abstract: A series of resveratrol/hydrazone hybrids were obtained and elucidated by spectroscopic analysis. All compounds were evaluated against colorectal cancer cells (SW480 and Sw620) and nonmalignant cell lines (HaCaT and CHO-K1) to establish the selectivity index.… read more here.
Keywords: resveratrol hydrazone; cancer cells; activity; hydrazone hybrids ... See more keywords
Evaluation of the Binding Relationship of the RdRp Enzyme to Novel Thiazole/Acid Hydrazone Hybrids Obtainable through Green Synthetic Procedure
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DOI: 10.3390/polym14153160
Abstract: The viral RNA-dependent RNA polymerase (RdRp) complex is used by SARS-CoV-2 for genome replication and transcription, making RdRp an interesting target for developing the antiviral treatment. Hence the current work is concerned with the green… read more here.
Keywords: binding relationship; evaluation binding; rdrp enzyme; hydrazone hybrids ... See more keywords