Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2016.11.030
Abstract: Abstract Based on our previous work, a series of hydrazone moiety-bearing aminopyrimidines were synthesized. The compounds were evaluated for inhibitory activities against EGFR T790M/L858R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring… read more here.
Keywords: moiety bearing; bearing aminopyrimidines; cancer cells; inhibition gefitinib ... See more keywords
Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112456
Abstract: ATX was capable of catalyzing the hydrolysis of LPC to the lipid mediator LPA which attracted considerable attention on the development of potent ATX inhibitors. Herein, driven by the HTS product indole-based lead 1, a… read more here.
Keywords: structure guided; atx inhibitors; moiety; hydrazone moiety ... See more keywords