Sulfonyl hydrazones derived from 3-formylchromone as non-selective inhibitors of MAO-A and MAO-B: Synthesis, molecular modelling and in-silico ADME evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.10.001
Abstract: A series of sulfonyl hydrazones derived from 3-formylchromone was synthesized and discovered to be effective, non-selective inhibitors of monoamine oxidases (MAO-A and MAO-B). The compounds are easily (synthetically) accessible in high yields, by simple condensation… read more here.
Keywords: sulfonyl hydrazones; hydrazones derived; mao; non selective ... See more keywords
Preparation and biological assessment of some aromatic hydrazones derived from hydrazides of phenolic acids and aromatic aldehydes
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05019
Abstract: There has been substantial interest over the past many years in the design of novel chemical compounds containing the azomethine group (-NH-N=CH) and exhibiting various medicinal properties such as antibacterial, antiviral, antifungal, and anti-inflammatory activities.… read more here.
Keywords: hydrazones derived; aromatic hydrazones; assessment aromatic; aromatic aldehydes ... See more keywords
Spatial structure and conformations of hydrazones derived from pyridoxal 5'-phosphate and 2-, 3-pyridinecarbohydrazide in the light of NMR study and quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117372
Abstract: Abstract Coordination properties and biological activity of the compounds depend significantly on their capability of taking the conformation, most appropriate for complex formation or binding to the target biomolecule. The hydrazones formed by B6 vitamers,… read more here.
Keywords: derived pyridoxal; hydrazones derived; phosphate pyridinecarbohydrazide; pyridoxal phosphate ... See more keywords