Palladium-Catalyzed Regio- and Diastereoselective Hydro(hetero)arylation for Rapid Construction of Quaternary Center Containing Cyclobutanes.
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DOI: 10.1021/acs.orglett.4c02645
Abstract: Herein we report a Pd-catalyzed regio- and diastereoselective hydro(hetero)arylation of inactivated alkylidenecyclobutanes. This protocol provides a rapid and atom-economical route to access 3-cyclobutyl (hetero)arenes with good functionalities toleration. With the assistance of the directing group,… read more here.
Keywords: hetero arylation; catalyzed regio; hydro hetero; diastereoselective hydro ... See more keywords