Nickel-Catalyzed Regio- and Enantioselective Hydroamination of Unactivated Alkenes Using Carbonyl Directing Groups.
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DOI: 10.1021/jacs.2c02343
Abstract: The asymmetric addition of an N-H bond to various alkenes via a direct catalytic method is a powerful way of synthesizing value-added chiral amines. Therefore, the enantio- and regioselective hydroamination of unactivated alkenes remains an… read more here.
Keywords: enantio regioselective; hydroamination unactivated; catalyzed regio; nickel catalyzed ... See more keywords
Hydroamination of Unactivated Alkenes with Aliphatic Azides.
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DOI: 10.1021/jacs.2c07643
Abstract: We report here an efficient and highly diastereoselective intermolecular anti-Markovnikov hydroamination of unactivated alkenes with aliphatic azides in the presence of silane. The system tolerates a wide range of azides and alkenes and operates with… read more here.
Keywords: alkenes aliphatic; hydroamination unactivated; unactivated alkenes; aliphatic azides ... See more keywords
Intermolecular Anti-Markovnikov Hydroamination of Unactivated Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer.
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DOI: 10.1021/jacs.7b11144
Abstract: Here we report a catalytic method for the intermolecular anti-Markovnikov hydroamination of unactivated alkenes using primary and secondary sulfonamides. These reactions occur at room temperature under visible light irradiation and are jointly catalyzed by an… read more here.
Keywords: anti markovnikov; hydroamination unactivated; proton coupled; markovnikov hydroamination ... See more keywords
Brønsted acid-catalysed intramolecular hydroamination of unactivated alkenes: metal triflates as an in situ source of triflic acid.
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DOI: 10.1039/c6dt04710f
Abstract: Hydroamination of alkenes or alkynes is one of the most straightforward methods to form C-N bonds and nitrogen-containing heterocycles. A simple Lewis acid Al(OTf)3 was found to be an effective precatalyst for the hydroamination of… read more here.
Keywords: triflic acid; nsted acid; hydroamination unactivated; metal triflates ... See more keywords
Regio- and chemoselective hydroamination of unactivated alkenes with anthranils via NiH-catalysis.
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DOI: 10.1039/d2cc07052a
Abstract: A NiH-catalyzed polarity-reversed hydroamination of β,γ-, γ,δ- and δ,ε-unsaturated alkenes with electrophilic anthranils was developed. This reaction proceeds in a highly regio- and chemoselective manner to afford γ, δ and ε-arylamines bearing a carbonyl or… read more here.
Keywords: hydroamination unactivated; regio chemoselective; hydroamination; chemoselective hydroamination ... See more keywords
Enantioselective hydroamination of unactivated terminal alkenes.
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DOI: 10.2139/ssrn.3936032
Abstract: Asymmetric alkene hydroamination could be a direct route to valuable chiral amines from abundant feedstocks. However, most asymmetric hydroaminations have limited synthetic value because they require a large excess of alkene, occur with modest enantioselectivity,… read more here.
Keywords: terminal alkenes; hydroamination unactivated; enantioselective hydroamination; hydroamination ... See more keywords