Palladium-Catalyzed Markovnikov Hydroaminocarbonylation of 1,1-Disubstituted and 1,1,2-Trisubstituted Alkenes for Formation of Amides with Quaternary Carbon.
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DOI: 10.1021/jacs.1c03454
Abstract: Hydroaminocarbonylation of alkenes is one of the most promising yet challenging methods for the synthesis of amides. Herein, we reported the development of a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation of 1,1-disubstituted or 1,1,2-trisubstituted alkenes… read more here.
Keywords: hydroaminocarbonylation disubstituted; quaternary carbon; catalyzed markovnikov; hydroaminocarbonylation ... See more keywords