2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes.
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100488
Abstract: A new mild and practically simple alkyne hydroarylation protocol for the synthesis of 3-(indol-3-yl)-3-(trifluoromethyl)acrylic acid esters by the reaction of indole derivatives with ethyl/methyl 4,4,4-trifluoro-3-(indol-3-yl)but-2-enoates in trifluoroethanol was developed. This method has the following advantages:… read more here.
Keywords: alkynes indoles; trifluoroethanol mediated; hydroarylation fluorinated; mediated hydroarylation ... See more keywords
Direct Coumarin Synthesis by Gold Catalyzed Hydroarylation of Alkynoic Acids/Esters
Sign Up to like & getrecommendations! Published in 2025 at "ChemCatChem"
DOI: 10.1002/cctc.202500465
Abstract: The combination of a gold(I) catalyst with a small amount of ionic liquid as solvent creates a catalytic system able to efficiently promote the direct synthesis of coumarins from phenols and alkynoic acids/esters, through a… read more here.
Keywords: gold catalyzed; alkynoic acids; acids esters; synthesis ... See more keywords
Synthesis of 12b‐methyl‐isoindoloisoquinolin‐8‐ones via Iridium‐Catalyzed Intramolecular Hydroarylation of Phenacyl Enamides
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500451
Abstract: We describe an intramolecular iridium‐catalyzed hydroarylation process for the synthesis of the title scaffold from phenacyl enamide substrates. This method achieves high yields while eliminating the requirement for pre‐functionalized substrates, as compared to Heck‐type cyclization… read more here.
Keywords: iridium; iridium catalyzed; 12b methyl; hydroarylation ... See more keywords
Molecular Design of Naphthalene- and Carbazole-Based Monomers for Regiospecific Synthesis of Poly(arylenevinylene)s via Co-Catalyzed Hydroarylation Polyaddition.
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202400168
Abstract: This study focuses on the development of regiospecific hydroarylation polyaddition of naphthalene- and carbazole-based monomers with diynes under mild reaction conditions at room temperature. A 1-pyrazole substituent serves as an appropriate directing group for a… read more here.
Keywords: reaction; hydroarylation polyaddition; naphthalene carbazole; hydroarylation ... See more keywords
Catalytic Hydroarylation of Alkenes with Phenols using B(C6F5)3
Sign Up to like & getrecommendations! Published in 2018 at "Organometallics"
DOI: 10.1021/acs.organomet.8b00621
Abstract: We demonstrate that tris(pentafluorophenyl)borane, B(C6F5)3, is shown to be an effective catalyst for the hydroarylation of olefins to yield substituted phenols. This system features fast reaction times, mild conditions, and good yields for a select… read more here.
Keywords: hydroarylation; using c6f5; alkenes phenols; catalytic hydroarylation ... See more keywords
Modular Synthesis of 9,10-Dihydroacridines through an ortho-C Alkenylation/Hydroarylation Sequence between Anilines and Aryl Alkynes in Hexafluoroisopropanol.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00487
Abstract: 9,10-Dihydroacridines are frequently encountered as key scaffolds in OLEDs. However, accessing those compounds from feedstock precursors typically requires multiple steps. Herein, a modular one-pot synthesis of 9,10-dihydroacridine frameworks is achieved through a reaction sequence featuring… read more here.
Keywords: hydroarylation; ortho alkenylation; aryl alkynes; sequence ... See more keywords
Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00700
Abstract: Intramolecular hydroarylation of alkenes through hydrogen atom transfer (HAT) represents a robust method to prepare benzo-fused heterocycles. However, the reported methods have limitations in a variety of accessible cyclic scaffolds. Here we report a dual… read more here.
Keywords: hydroarylation; hydrogen atom; cobalt photoredox; hydroarylation alkenes ... See more keywords
Gold(I)-Catalyzed Selective Hydroarylation of Indoles with Haloalkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01921
Abstract: A highly regio- and stereoselective synthesis of a Z-alkenyl indole via the gold-catalyzed addition of an indole to a haloalkyne was developed. In the presence of gold catalyst SIPrAuCl and cocatalyst NaBARF, a broad range… read more here.
Keywords: hydroarylation; selective hydroarylation; indoles haloalkynes; hydroarylation indoles ... See more keywords
Dearomative Cyclization/Spirocyclization via Electrochemical Reductive Hydroarylation of Nonactivated Arenes.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02862
Abstract: An electrochemical cyclization/spirocyclization hydroarylation via reductive dearomatization of a series of nonactivated arenes including N-substituted indoles, indole-3-carboxamide derivatives, and iodo-substituted benzamides is described. This protocol boasts high atom efficiency, broad substrate applicability, and excellent selectivity.… read more here.
Keywords: cyclization spirocyclization; dearomative cyclization; hydroarylation; nonactivated arenes ... See more keywords
Nickel-Catalyzed Regioselective Ring-Opening Hydroarylation of Methylenecyclopropanes.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01238
Abstract: The hydroarylation of methylenecyclopropanes (MCPs) is a challenging process due to the difficulty in controlling regioselectivity and the complex reaction patterns involved. Herein, we report a simple external ligand-free Ni-catalyzed ring-opening hydroarylation of MCPs with… read more here.
Keywords: nickel catalyzed; hydroarylation; ring opening; catalyzed regioselective ... See more keywords
Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01228
Abstract: A cobalt(III) catalyzed hydroarylation of Michael acceptors using indolines, selectively at the C-7 position, has been reported. For the selective C-7 functionalization of indoline, we have used a weakly coordinating amide carbonyl group. During the… read more here.
Keywords: hydroarylation; catalyzed hydroarylation; weakly coordinating; hydroarylation michael ... See more keywords