The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14434
Abstract: p27Kip1 functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27Kip1 also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a… read more here.
Keywords: hydrocarbon receptor; p27kip1; dependent kinase; cyclin dependent ... See more keywords
Kynurenine produced by tryptophan 2,3‐dioxygenase metabolism promotes glioma progression through an aryl hydrocarbon receptor‐dependent signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11833
Abstract: The current studies associated with tumor biology continue to describe a high correlation between tryptophan (Trp) metabolism and tumor progression. These findings reflect the complex underlying mechanism of tumor development and highlight the need to… read more here.
Keywords: hydrocarbon receptor; metabolism; trp metabolism; aryl hydrocarbon ... See more keywords
The aryl hydrocarbon receptor modulates the function of human CD56bright NK cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747289
Abstract: Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR)… read more here.
Keywords: cd56bright; hydrocarbon receptor; aryl hydrocarbon; function ... See more keywords
Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T‐helper 2‐driven proinflammatory responses in a mouse model of allergic dermatitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3782
Abstract: The aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that binds to various environmental chemicals and contributes to numerous toxicological effects. However, the direct effects of AhR on the development of allergic diseases are… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; benzo pyrene; activation ... See more keywords
GSH/GSSG redox couple plays central role in aryl hydrocarbon receptor‐dependent modulation of cytochrome P450 1A1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22164
Abstract: The redox regulation of aryl hydrocarbon receptor (AHR) target genes such as the best characterized, cytochrome P450 1A1 (CYP1A1) has not been known. Therefore the aim of this study was to explore how cellular redox… read more here.
Keywords: gssg; p450 1a1; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Aryl hydrocarbon receptor engagement during redox alteration determines the fate of CD4+ T cells in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22821
Abstract: The preservation of the redox homeostasis is critical for cell survival and functionality. Redox imbalance is an essential inducer of several pathological states. CD4+/helper T cells are highly dependent on the redox state of their… read more here.
Keywords: redox alteration; hydrocarbon receptor; aryl hydrocarbon; redox ... See more keywords
Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13246
Abstract: The aryl hydrocarbon receptor (AHR) is expressed in the intestine and liver, where it has pleiotropic functions and target genes. This study aims to explore the potential implication of AHR in cancer cachexia, an inflammatory… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; cancer cachexia; cancer ... See more keywords
Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine‐specific homeobox expression
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22658
Abstract: The aryl hydrocarbon receptor (AHR), a major chemical sensor, is thought to play a role in various biological contexts, including cell cycle regulation and tumorigenesis. However, its regulatory mechanisms remain unclear. We propose herein a… read more here.
Keywords: tumorigenesis; intestine specific; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
The aryl hydrocarbon receptor in liver inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-021-00867-8
Abstract: The aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated transcription factor with multifaceted physiological functions. In the immune system, AHR has been unequivocally identified as a key regulatory factor that can integrate environmental, dietary,… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; inflammation; liver ... See more keywords
Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09499-z
Abstract: The aryl hydrocarbon receptor (AHR) is a ligand-activated receptor that regulates the metabolism of several xenobiotics and participates in ocular inflammation. Although severe inflammation is a major risk of retinal damage, the underlying mechanism is… read more here.
Keywords: socs3; hydrocarbon receptor; ahr; stat3 ... See more keywords
Promoting epithelial-to-mesenchymal transition by d-kynurenine via activating aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3323-y
Abstract: Epithelial-to-mesenchymal transition (EMT) is believed to play key roles in the process of cancer metastasis. The molecular changes during EMT are characterized by the down-regulation of epithelial proteins, such as E-cadherin, and the up-regulation of… read more here.
Keywords: kynurenine; mesenchymal transition; hydrocarbon receptor; aryl hydrocarbon ... See more keywords