Hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery.
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DOI: 10.1039/d0cc06312f
Abstract: The effects of all-hydrocarbon cross-linking on the cell-penetrating properties of Tat were systematically investigated. These stapled cell-penetrating peptides were designed to exhibit a cationic secondary amphipathic profile. We found that the hydrophobicity and helical conformation… read more here.
Keywords: cell penetrating; tat peptides; stapled tat; hydrocarbon staple ... See more keywords