Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01130
Abstract: All-hydrocarbon stapled peptides make up a promising class of protein-protein interaction regulators; their potential therapeutic benefit arises because they have a high binding affinity and specificity for intracellular molecules. The cell permeation efficacy of these… read more here.
Keywords: cellular uptake; hydrocarbon stapled; stapled peptides; hydrophobicity ... See more keywords
Design, Synthesis, and Antitumor Activity Study of All-Hydrocarbon-Stapled B1-Leu Peptides
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DOI: 10.3389/fchem.2022.840131
Abstract: B1-Leu peptide is a structural optimization compound derived from the lysine- and phenylalanine-rich antimicrobial peptide Cathelicidin-BF. It has shown promising antibacterial and antitumor biological activity. However, linear peptides are not the best choice for novel… read more here.
Keywords: antitumor activity; activity; stapled leu; hydrocarbon stapled ... See more keywords
Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
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DOI: 10.3389/fphar.2022.891041
Abstract: The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1,… read more here.
Keywords: stapled peptides; primary interface; ca2; hydrocarbon stapled ... See more keywords