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   Articles with "hydrocarbon stapling" as a keyword



Hydrocarbon stapling modification of peptide alyteserin‐2a: Discovery of novel stapled peptide antitumor agents

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recommendations! Published in 2022 at "Journal of Peptide Science"

DOI: 10.1002/psc.3401

Abstract: Alyteserin‐2a (ILGKLLSTAAGLLSNLNH2) is isolated from the skin exudates of midwife toad and has a wide range of biological applications. However, the use of alyteserin‐2a as an antitumor agent is limited due to its structural flexibility.… read more here.

Keywords: hydrocarbon stapling; antitumor; modification peptide; peptide alyteserin ... See more keywords

De Novo Hydrocarbon-Stapling Design of Single-Turn α-Helical Antimicrobial Peptides

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recommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-019-09964-7

Abstract: Most existing antimicrobial peptides (AMPs) are α-helical and cationic that exhibit typical amphipathic feature to facilitate efficient interaction with bacterial outer membranes. However, short α-helix is unstable in water, and thus naturally occurring α-helical AMPs… read more here.

Keywords: design; hydrocarbon; single turn; antimicrobial peptides ... See more keywords

Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01744

Abstract: The threats of drug resistance and new emerging pathogens have led to an urgent need to develop alternative treatment therapies. Recently, considerable research efforts have focused on membrane-active peptides (MAPs), a category of peptides in… read more here.

Keywords: active peptides; hydrocarbon stapling; membrane active; design ... See more keywords

Discovery of novel antibacterial agent for the infected wound treatment: all-hydrocarbon stapling optimization of LL-37

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recommendations! Published in 2024 at "Theranostics"

DOI: 10.7150/thno.87916

Abstract: Rationale: Antimicrobial peptide LL-37 has been recognized as a favorable alternative to antibiotics due to its broad antibacterial spectrum, low resistance development and diverse biological activities. However, its high manufactory cost, poor proteolytic stability, and… read more here.

Keywords: treatment; hydrocarbon stapling; infected wound; hydrocarbon ... See more keywords