Hydrocarbon stapling modification of peptide alyteserin‐2a: Discovery of novel stapled peptide antitumor agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3401
Abstract: Alyteserin‐2a (ILGKLLSTAAGLLSNLNH2) is isolated from the skin exudates of midwife toad and has a wide range of biological applications. However, the use of alyteserin‐2a as an antitumor agent is limited due to its structural flexibility.… read more here.
Keywords: hydrocarbon stapling; antitumor; modification peptide; peptide alyteserin ... See more keywords
De Novo Hydrocarbon-Stapling Design of Single-Turn α-Helical Antimicrobial Peptides
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DOI: 10.1007/s10989-019-09964-7
Abstract: Most existing antimicrobial peptides (AMPs) are α-helical and cationic that exhibit typical amphipathic feature to facilitate efficient interaction with bacterial outer membranes. However, short α-helix is unstable in water, and thus naturally occurring α-helical AMPs… read more here.
Keywords: design; hydrocarbon; single turn; antimicrobial peptides ... See more keywords
Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides.
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DOI: 10.1021/acs.jmedchem.1c01744
Abstract: The threats of drug resistance and new emerging pathogens have led to an urgent need to develop alternative treatment therapies. Recently, considerable research efforts have focused on membrane-active peptides (MAPs), a category of peptides in… read more here.
Keywords: active peptides; hydrocarbon stapling; membrane active; design ... See more keywords