Supramolecular assembly in the epiisopiloturine hydrochloride salt
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DOI: 10.1016/j.molstruc.2017.01.081
Abstract: Abstract Epiisopiloturine hydrochloride (Epi-HCl) salt was synthetized from epiisopiloturine, an in vivo anthelmintic compound against Schistosoma mansoni worms. Despite there being no acute toxicity in mammalian cells, the compound's water insolubility makes its administration difficult. In… read more here.
Keywords: assembly epiisopiloturine; epi hcl; epiisopiloturine hydrochloride; supramolecular assembly ... See more keywords
Hydrochloride Salt of the GABAkine KRM-II-81
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DOI: 10.1021/acsomega.2c03029
Abstract: Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABAA receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many seizure and pain models in rodents, where it exhibits improved pharmacological properties… read more here.
Keywords: krm; hydrochloride salt; krm hcl; salt ... See more keywords
Suppressed hydration in metoclopramide hydrochloride by salt cocrystallisation
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DOI: 10.1039/c8ce00129d
Abstract: Metoclopramide (MCP), a widely used antiemetic drug, is marketed as hydrochloride salt existing in the monohydrate and anhydrate forms. In this study, the hydration/dehydration behaviour of MCP hydrochloride salt was investigated by thermal and crystal… read more here.
Keywords: salt; form; hydrochloride salt; salt cocrystallisation ... See more keywords
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt
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DOI: 10.1093/toxsci/kfaa191
Abstract: Abstract Poor solubility of drug candidates mainly affects bioavailability, but poor solubility of drugs and metabolites can also lead to precipitation within tissues, particularly when high doses are tested. RO0728617 is an amphoteric compound bearing… read more here.
Keywords: crystal deposition; drug; compound; solubility ... See more keywords