Hypopituitarism Induced by Continuous Infusion of PGI2 Analogues: A Case Series and the Role of ACTH Screening and Hydrocortisone Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Pulmonary Circulation"
DOI: 10.1002/pul2.70116
Abstract: ABSTRACT Hypopituitarism has been reported in patients receiving continuous infusions of prostaglandin I2 (PGI2) analogues for pulmonary hypertension (PH). However, these patients' clinical characteristics, treatment, and prognoses remain unclear. This retrospective multicentre study included 22… read more here.
Keywords: treatment; hypopituitarism; infusion; hydrocortisone ... See more keywords
Effects of topical low-dose preservative-free hydrocortisone on intraocular pressure in patients affected by ocular surface disease with and without glaucoma
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05345-3
Abstract: This study aims to investigate the safety and efficacy of short-term treatment for ocular surface disease (OSD) with topical low-dose (1,005 mg) preservative-free hydrocortisone in one hundred patients with and without glaucoma. This was an… read more here.
Keywords: topical low; low dose; hydrocortisone; free hydrocortisone ... See more keywords
A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-024-09934-7
Abstract: Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the drug-of-choice for cortisol replacement therapy, aiming to mimic physiological cortisol circadian rhythm. The hypothalamic-pituitary-adrenal (HPA) axis controls cortisol production… read more here.
Keywords: physiology; replacement therapy; hydrocortisone; cortisol replacement ... See more keywords
Does quality of life differ in patients with Addison’s disease on different glucocorticoid therapies?
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1716-z
Abstract: Dear Editor, In March’s issue of Endocrine, Meyer et al. [1] found that fluctuations in self-reported scores of quality of life (via AddiQoL) correlated to a state of ‘pre-crisis’ in patients with Addison’s disease. Patients… read more here.
Keywords: hydrocortisone; patients addison; glucocorticoid; quality life ... See more keywords
Adrenal insufficiency treated with conventional hydrocortisone leads to elevated levels of Interleukin-6: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine"
DOI: 10.1007/s12020-019-01956-3
Abstract: Adrenal insufficiency is a rare disease with an estimated prevalence of 100–126 cases per million for primary adrenal insufficiency (PAI) and 450 cases per million for secondary/tertiary adrenal insufficiency (SAI/TAI) [1, 2]. Glucocorticoid replacement therapy… read more here.
Keywords: hydrocortisone; pilot study; treated conventional; adrenal insufficiency ... See more keywords
The effect of dual-release versus conventional hydrocortisone on fatigue, measured by ecological momentary assessments
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine"
DOI: 10.1007/s12020-020-02507-x
Abstract: Purpose Replicating the physiological cortisol secretion is key in the treatment of glucocorticoid insufficient individuals and optimization may enhance quality of life. The study investigates fatigue measured by ecological momentary assessments in patients treated with… read more here.
Keywords: fatigue measured; measured ecological; hydrocortisone; fatigue ... See more keywords
The urinary cortisol metabolome in patients with adrenal insufficiency: Dual-release hydrocortisone is less deleterious than conventional hydrocortisone therapy
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.04.004
Abstract: Introduction Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy provides a more physiological cortisol profile than conventional thrice-daily (TID) therapy and has demonstrated improved metabolic profile among patients with adrenal insufficiency (AI). The mechanisms by which… read more here.
Keywords: dual release; cortisol; patients adrenal; hydrocortisone ... See more keywords
Acute effect of hydrocortisone for respiratory deterioration in preterm infants: Oxygenation, ventilation, vital signs, and electrolytes.
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DOI: 10.1016/j.earlhumdev.2021.105320
Abstract: BACKGROUND Preterm infants with severe bronchopulmonary dysplasia require rescue therapy with glucocorticoids, and hydrocortisone is increasingly replacing dexamethasone. The standard for rescue therapy is unclear. AIM To quantify the short-term effects of respiratory rescue hydrocortisone… read more here.
Keywords: range; hydrocortisone; spo2 fio2; preterm infants ... See more keywords
Surfactants from itaconic acid: Toxicity to HaCaT keratinocytes in vitro, micellar solubilization, and skin permeation enhancement of hydrocortisone.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.056
Abstract: One of the most widely used approaches for improving drug permeation across the stratum corneum barrier of the skin is the use of chemical penetration enhancers, such as surfactants. In this study, two anionic surfactants,… read more here.
Keywords: hydrocortisone; permeation; skin; itaconic acid ... See more keywords
Severe Leptospirosis with Pulmonary Hemorrhage; The Role of Intravenous Hydrocortisone
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Infection and Public Health"
DOI: 10.1016/j.jiph.2020.01.182
Abstract: Leptospirosis is an endemic zoonosis caused by spirochetes of the genus Leptospira that typically occurs in tropical regions. Pulmonary hemorrhage which is the frequent cause of mortality in leptospirosis is either underdiagnosed or only discovered… read more here.
Keywords: hydrocortisone; leptospirosis; severe leptospirosis; pulmonary hemorrhage ... See more keywords
Hydrocortisone administration for reducing post-traumatic stress symptoms: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2021.105168
Abstract: BACKGROUND Post-traumatic stress disorder (PTSD) is a debilitating disorder that is often accompanied by alterations in the hypothalamic-pituitary (HPA) axis. While there is abundant evidence for the efficacy of psychological therapies in reducing post-traumatic stress… read more here.
Keywords: post traumatic; hydrocortisone; reducing post; stress symptoms ... See more keywords