A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.
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DOI: 10.1016/j.bbrc.2017.04.125
Abstract: Huntington's disease (HD) has been recently shown to have a horizontally transmitted, prion-like pathology. Thus, the migration of polyglutamine-containing aggregates to acceptor cells is important for the progression of HD. These aggregates contain glyceraldehyde-3-phosphate dehydrogenase… read more here.
Keywords: polyglutamine; binds gapdh; toxicity; hydrocortisone derivative ... See more keywords