Hydrocyanation of Non‐Activated Alkenes Without Handling HCN
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DOI: 10.1002/ejoc.202400527
Abstract: The hydrocyanation of alkenes can be considered a straightforward methodology that gives access to different functionalized organic chemistry entities. This is due to nitrile's high versatility, which can easily undergo further transformations. However, this process… read more here.
Keywords: hydrocyanation; chemistry; non activated; activated alkenes ... See more keywords
Nickel-Catalyzed Asymmetric Hydrocyanation of Allenes.
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DOI: 10.1021/acs.orglett.9b03938
Abstract: The first catalytic enantioselective hydrocyanation of allenes catalyzed by a (R,R)-Ph-BPE-Ni(0) complex catalyst has been accomplished. Numerous optically active allylic nitriles were obtained in good yield with excellent enantioselectivities (up to 98% ee). read more here.
Keywords: catalyzed asymmetric; hydrocyanation; hydrocyanation allenes; asymmetric hydrocyanation ... See more keywords
Development and mechanistic studies of calcium–BINOL phosphate-catalyzed hydrocyanation of hydrazones
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DOI: 10.3762/bjoc.21.59
Abstract: Asymmetric hydrocyanation of hydrazones, catalyzed by a calcium–BINOL phosphate complex, has been studied for the first time both experimentally and computationally with DFT methods. A full catalytic cycle for the enantioselective synthesis of α-hydrazinonitriles is… read more here.
Keywords: hydrocyanation; catalyst; hydrocyanation hydrazones; binol phosphate ... See more keywords
Regioselective formal hydrocyanation of allenes: synthesis of β,γ-unsaturated nitriles with α-all-carbon quaternary centers
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DOI: 10.3762/bjoc.21.63
Abstract: This study introduces a highly selective hydrocyanation method based on copper-catalyzed hydroalumination of allenes with diisobutylaluminum hydride, followed by the regio- and stereoselective allylation with p-toluenesulfonyl cyanide. The proposed methodology is efficient for accessing acyclic… read more here.
Keywords: carbon quaternary; hydrocyanation; unsaturated nitriles; nitriles carbon ... See more keywords