Hydrofunctionalization of Polyunsaturated Hydrocarbons via Palladium(0) π‐Lewis Base‐Mediated Protonation
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DOI: 10.1002/cctc.202501167
Abstract: Palladium(0)‐catalyzed asymmetric hydrofunctionalization of polyunsaturated hydrocarbons offers an atom‐economic and highly stereoselective strategy for the synthesis of chiral molecules. Traditionally, these transformations are initiated via well‐established mechanisms such as Pd─H insertion or ligand‐to‐ligand hydrogen transfer… read more here.
Keywords: hydrofunctionalization polyunsaturated; polyunsaturated hydrocarbons; lewis base; protonation ... See more keywords
Recent Advances in Radical Hydrofunctionalization of Alkenes and Dienes via Reductive Metal‐Hydride Hydrogen Atom Transfer (MHAT)
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DOI: 10.1002/ejoc.202401103
Abstract: The metal‐hydride hydrogen atom transfer strategy (MHAT) has emerged as a robust approach for the radical hydrofunctionalization of alkenes, demonstrating exceptional functional group tolerance and chemoselectivity. Traditional methods for generating metal‐hydride (M‐H) species typically require… read more here.
Keywords: hydride hydrogen; hydrogen atom; metal hydride; hydrofunctionalization ... See more keywords
Iron- and Cobalt-Catalyzed Asymmetric Hydrofunctionalization of Alkenes and Alkynes.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00212
Abstract: ConspectusTransition metal catalyzed asymmetric hydrofunctionalization of readily available unsaturated hydrocarbons presents one of the most straightforward and atom-economic protocols to access valuable optically active products. For decades, noble transition metal catalysts have laid the cornerstone… read more here.
Keywords: hydrofunctionalization; metal; ligand; earth abundant ... See more keywords
Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization
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DOI: 10.1021/acscatal.0c01209
Abstract: A general protocol has been developed for the Markovnikov-selective intermolecular hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature involves the photoche... read more here.
Keywords: dual cobalt; hydrofunctionalization; catalysis; catalysis enabled ... See more keywords
Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07807
Abstract: Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions─hydroesterification, hydroamination, and hydroetherification─enabled by organophotoredox catalysis. All three reactions are found to proceed via initial oxidation of the… read more here.
Keywords: hydrofunctionalization; anti markovnikov; nucleophilic attack; rate limiting ... See more keywords
Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo00734a
Abstract: Diverse anti-Markovnikov hydrofunctionalization of alkenols triggered by the addition of S-, P-, and C-centered radicals to alkenes followed by intramolecular 1,5(6)-hydrogen atom transfer (HAT) with remote α-C–H bonds of alcohols has been developed. The strategy… read more here.
Keywords: alkenols triggered; hydrofunctionalization alkenols; hydrogen atom; hydrofunctionalization ... See more keywords
A photo- and cobalt-catalyzed highly selective and divergent hydrofunctionalization of 1,3-dienes with phenols
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DOI: 10.1039/d5sc00438a
Abstract: An applicable cobalt-hydride-mediated selective, divergent hydroetherification and sequential hydroetherification/hydroarylation of 1,3-dienes with simple phenol feedstocks under a photoredox and cobalt catalytic system have been developed. A variety of allyl aryl ethers and value-added chroman derivatives… read more here.
Keywords: divergent; selective divergent; hydrofunctionalization; cobalt catalyzed ... See more keywords