Hydrogel matrix presence and composition influence drug responses of encapsulated glioblastoma spheroids.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.005
Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor with median patient survival of 12-15 months. To facilitate treatment development, bioengineered GBM models that adequately recapitulate the in vivo tumor microenvironment are needed. Matrix-encapsulated multicellular… read more here.
Keywords: gbm spheroid; drug responses; hydrogel matrix; matrix ... See more keywords
Progressive Local Accumulation of Self-Assembled Nanoreactors in a Hydrogel Matrix through Repetitive Injections of ATP
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13504
Abstract: Cellular functions are regulated with high spatial control through the local activation of chemical processes in a complex inhomogeneous matrix. The development of synthetic macroscopic systems with a similar capacity allows fundamental studies aimed at… read more here.
Keywords: unassembled amphiphiles; self assembled; hydrogel matrix; accumulation self ... See more keywords
A Novel Injectable Hydrogel Matrix Loaded With 90Y Microspheres for the Treatment of Solid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15540
Abstract: Background/Aim: The need to concentrate the anti-tumoral activity of 90Y only to the targeted tumor, while minimizing its off-target effects, led to the development of an innovative device (BAT-90) composed of a hydrogel matrix and… read more here.
Keywords: 90y microspheres; novel injectable; hydrogel matrix; treatment ... See more keywords
κ-Carrageenan Hydrogel as a Matrix for Therapeutic Enzyme Immobilization
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14194071
Abstract: During the last few decades, polysaccharide hydrogels attract more and more attention as therapeutic protein delivery systems due to their biocompatibility and the simplicity of the biodegradation of natural polymers. The protein retention by and… read more here.
Keywords: immobilization; therapeutic enzyme; carrageenan hydrogel; hydrogel matrix ... See more keywords