Ru-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl-Substituted Alkenes and Substrate-Mediated H/D Exchange.
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DOI: 10.1021/acscatal.1c05061.s001
Abstract: A highly efficient and enantioselective asymmetric hydrogenation catalyzed by Ru-DTBM-segphos is reported for a broad range of pyridine-pyrroline tri-substituted alkenes. Kinetic, spectroscopic, and computational studies suggest that addition of H2 is rate-determining and that alkene… read more here.
Keywords: hydrogenation; exchange; hydrogenation pyridyl; enantioselective hydrogenation ... See more keywords