The α/β Hydrolase AzpM Catalyzes Dipeptide Synthesis in Alazopeptin Biosynthesis Using Two Molecules of Carrier Protein‐Tethered Amino Acid
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100700
Abstract: During the biosynthesis of alazopeptin, a tripeptide composed of two molecules of 6‐diazo‐5‐oxo‐L‐norleucine (DON) and one of alanine, the α/β hydrolase AzpM synthesizes the DON‐DON dipeptide using DON tethered to the carrier protein AzpF (DON‐AzpF).… read more here.
Keywords: azpf; two molecules; carrier protein; azpm ... See more keywords
Evidence for the Early Evolutionary Loss of the M20D Auxin Amidohydrolase Family from Mosses and Horizontal Gene Transfer from Soil Bacteria of Cryptic Hydrolase Orthologues to Physcomitrella patens
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-019-09945-6
Abstract: Inactive auxin conjugates are accumulated in plants and hydrolyzed to recover phytohormone action. A family of metallopeptidase orthologues has been conserved in Plantae to help regulate auxin homeostatic levels during growth and development. This hydrolase… read more here.
Keywords: physcomitrella patens; soil bacteria; family; hydrolase ... See more keywords
Purification and Characterization of a Novel Hydrolase That Can Specifically Degrade the Polysaccharide Isolated from Green Seaweed Ulva prolifera
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ocean University of China"
DOI: 10.1007/s11802-019-3687-y
Abstract: The extracellular polysaccharide hydrolase-producing strain EP-1 was isolated from seawater and identified as Paenibacillus pabuli. Furthermore, a homogeneous extracellular polysaccharide hydrolase from Paenibacillus pabuli EP-1 was purified by combining ion-exchange chromatography and size exclusion chromatography… read more here.
Keywords: polysaccharide hydrolase; activity; hydrolase; ulva prolifera ... See more keywords
A lysosomal hydrolase receptor, CPBF2, is associated motility and invasion of the enteric protozoan parasite Entamoeba histolytica.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2020.111299
Abstract: Proper targeting and secretion of lysosomal hydrolases are regulated by transporting receptors. Entamoeba histolytica, the enteric protozoan parasite responsible for human amebiasis, has a unique family of lysosomal hydrolase receptors, cysteine protease binding protein family,… read more here.
Keywords: invasion; hydrolase; motility; entamoeba histolytica ... See more keywords
A maize hydrolase with activity against maize insect and fungal pests
Sign Up to like & getrecommendations! Published in 2020 at "Plant Gene"
DOI: 10.1016/j.plgene.2019.100214
Abstract: Abstract A gene annotated as a chitinase-like protein that occurred in a quantitative trait locus for fungal maize ear rot resistance was cloned from a maize inbred with Fusarium proliferatum/verticillioides resistance. The protein sequence was… read more here.
Keywords: protein; pests maize; hydrolase; resistance ... See more keywords
Utilizing a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152547
Abstract: Abstract Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase… read more here.
Keywords: batatasin; leukotriene hydrolase; copper free; hydrolase ... See more keywords
Variant Bacterial Riboswitches Associated with Nucleotide Hydrolase Genes Sense Nucleoside Diphosphates.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00617
Abstract: The ykkC RNA motif was a long-standing orphan riboswitch candidate that has recently been proposed to encompass at least five distinct bacterial riboswitch classes. Most ykkC RNAs belong to the subtype 1 group, which are… read more here.
Keywords: variant bacterial; nucleoside diphosphates; sense; hydrolase ... See more keywords
Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01507
Abstract: Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and… read more here.
Keywords: soluble epoxide; epoxide hydrolase; hydrolase; seh inhibitors ... See more keywords
Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00614
Abstract: In human plasma, the main agent of hydrolysis of the ester-type prodrug of levodopa, designated ONO-2160, is alpha-1-acid glycoprotein (AGP), which is a mixture of the F1*S and A variants at molar ratios of 3:1… read more here.
Keywords: ono 2160; acid glycoprotein; activity; hydrolysis ... See more keywords
High-Throughput Characterization and Optimization of Polyamide Hydrolase Activity Using Open Port Sampling Interface Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.3c00097
Abstract: Enzymatic biodegradation of polymers, such as polyamides (PA), has the potential to cost-effectively reduce plastic waste, but enhancements in degradation efficiency are needed. Engineering enzymes through directed evolution is one pathway toward identification of critical… read more here.
Keywords: port sampling; mass spectrometry; open port; hydrolase ... See more keywords
Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15529
Abstract: Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe that can cause nosocomial antibiotic-associated intestinal disease. Although the production of toxin A (TcdA) and toxin B (TcdB) contribute to the main pathogenesis of C. difficile, the… read more here.
Keywords: clostridioides difficile; difficile r20291; hydrolase; cwl0971 ... See more keywords