Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.187
Abstract: Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and… read more here.
Keywords: alisma orientale; soluble epoxide; hydrolase inhibitors; epoxide hydrolase ... See more keywords
Soluble epoxide hydrolase inhibitors might prevent ischemic arrhythmias via microRNA-1 repression in primary neonatal mouse ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c6mb00824k
Abstract: Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent arrhythmias; however, the underlying molecular mechanisms remain unclear. In recent years, the proarrhythmic… read more here.
Keywords: soluble epoxide; hydrolase inhibitors; epoxide hydrolase; mir ... See more keywords
Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade.
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2022.2054329
Abstract: INTRODUCTION Biological effects mediated by the CYP450 arm of arachidonate cascade implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory epoxy fatty acids to pro-inflammatory diols. Hence, inhibiting the sEH offers a therapeutic approach to… read more here.
Keywords: epoxide hydrolase; seh; soluble epoxide; last decade ... See more keywords
Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction
Sign Up to like & getrecommendations! Published in 2018 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-018-0780-y
Abstract: BackgroundIt has been demonstrated that soluble epoxide hydrolase inhibitors (sEHIs) are protective against ischemia-induced lethal arrhythmias, but the mechanisms involved are unknown. Previously, we showed that sEHIs might reduce the incidence of ischemic arrhythmias by… read more here.
Keywords: soluble epoxide; aucb; hydrolase inhibitors; epoxide hydrolase ... See more keywords