LAUSR

Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors

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1 Published in 2022 at "ChemMedChem"

DOI: 10.1002/cmdc.202200137

Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation‐related pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and… read more here.

Keywords: seh; seh inhibitors; soluble epoxide; epoxide hydrolase ... See more keywords

Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors

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2 Published in 2023 at "ACS Omega"

DOI: 10.1021/acsomega.2c06936

Abstract: Inhibition of soluble epoxide hydrolase (sEH) is indicated as a new therapeutic modality against a variety of inflammatory diseases, including metabolic, renal, and cardiovascular disorders. In our ongoing research on sEH inhibitors, we synthesized novel… read more here.

Keywords: seh; benzoxazolone urea; seh inhibitors; soluble epoxide ... See more keywords