Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology
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DOI: 10.1177/2472555217737006
Abstract: Protein mono-ADP-ribosylation is a posttranslational modification involved in the regulation of several cellular signaling pathways. Cellular ADP-ribosylation is regulated by ADP-ribose hydrolases via a hydrolysis of the protein-linked ADP-ribose. Most of the ADP-ribose hydrolases share… read more here.
Keywords: inhibitor screening; development inhibitor; hydrolyzing macrodomains; adp ribose ... See more keywords