Oxycodone, Hydromorphone, and the Risk of Suicide: A Retrospective Population-Based Case–Control Study
Sign Up to like & getrecommendations! Published in 2020 at "Drug Safety"
DOI: 10.1007/s40264-020-00924-5
Abstract: Introduction Opioids have been increasingly associated with suicide, but whether they are independent contributors is unclear. Oxycodone and hydromorphone are commonly prescribed high-potency opioids that can differentially affect mood. Objective The objective of this study… read more here.
Keywords: hydromorphone; study; case; oxycodone hydromorphone ... See more keywords
Treatment with injectable hydromorphone: Comparing retention in double blind and open label treatment periods.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of substance abuse treatment"
DOI: 10.1016/j.jsat.2019.03.012
Abstract: BACKGROUND In a double-blind, non-inferiority randomized controlled trial injectable hydromorphone, a licensed short acting opioid analgesic, was shown to be as effective as diacetylmorphine for the treatment of severe opioid use disorder. An appropriate question… read more here.
Keywords: double blind; treatment; retention; hydromorphone ... See more keywords
Hydromorphone protects CA1 neurons by activating mTOR pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.09.029
Abstract: Hydromorphone has been shown to play protective effect in rat glial cell. However, whether hydromorphone plays important roles in ischemia-reperfusion (IR) injury and the involved signaling pathway remains unclear. In this study, we detected whether… read more here.
Keywords: ca1 neurons; hydromorphone; pathway; activating mtor ... See more keywords
The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2018.11.001
Abstract: OBJECTIVE Describe the pharmacokinetics and pharmacodynamics of intravenous hydromorphone in healthy horses. STUDY DESIGN Masked, randomized, cross-over, Latin square design. ANIMALS A group of eight healthy adult horses METHODS: Horses were administered each of four… read more here.
Keywords: baseline treatments; treatment; pharmacokinetics pharmacodynamics; hydromorphone ... See more keywords
Pharmacokinetics of subcutaneously administered hydromorphone in bearded dragons (Pogona vitticeps) and red-eared slider turtles (Trachemys scripta elegans).
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2018.12.002
Abstract: OBJECTIVE To determine pharmacokinetic dosing strategy in bearded dragons (Pogona vitticeps) and red-eared sliders (Trachemys scripta elegans) based on two subcutaneously (SC) administered doses of hydromorphone (0.5 and 1.0 mg kg-1). STUDY DESIGN Randomized crossover… read more here.
Keywords: bearded dragons; slider turtles; hydromorphone; red eared ... See more keywords
Pattern of hydromorphone use in King Abdulaziz Medical City-Central Region (KAMC-CR)
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88276-7
Abstract: Hydromorphone is a semi-synthetic opioid that acts mainly on the μ-opioid receptor. Hydromorphone has a fast onset of action, usually within 5 min, and its effectiveness peaks at approximately 20 min, which makes it favourable… read more here.
Keywords: use; medical city; hydromorphone; abdulaziz medical ... See more keywords
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2076866
Abstract: The opioid agonist hydromorphone is indicated for the management of severe acute and chronic pain given that alternate treatments are insufficient. While the genotoxicity profile of hydromorphone is well investigated, little is known about the… read more here.
Keywords: vitro; silico; bishydromorphone; micronucleus test ... See more keywords
A Comparison of Institutional Opioid Equianalgesia Tools: A National Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of palliative medicine"
DOI: 10.1089/jpm.2021.0678
Abstract: Context: Equianalgesic tools are commonly utilized to guide dose of analgesic therapy, but there is no national consensus on equianalgesic calculations in the United States. Objectives: To propose a summary of current opioid equianalgesic data… read more here.
Keywords: opioid equianalgesia; equianalgesia tools; guidance; equianalgesic tools ... See more keywords
Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients with Renal Impairment and Cancer Pain.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of palliative medicine"
DOI: 10.1089/jpm.2022.0289
Abstract: Background: The opioid analgesic hydromorphone has a low renal excretion ratio; however, exposure after oral administration is several times higher in those with moderate or severe renal impairment. Objectives: We evaluated the impact of renal… read more here.
Keywords: moderate severe; steady state; hydromorphone; renal impairment ... See more keywords
Comparative Effectiveness of Targeted Intrathecal Drug Delivery Using a Combination of Bupivacaine with Either Low-Dose Fentanyl or Hydromorphone in Chronic Back Pain Patients with Lumbar Postlaminectomy Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Pain medicine"
DOI: 10.1093/pm/pnaa104
Abstract: OBJECTIVE Targeted intrathecal drug delivery (TIDD) is an effective interventional pain management modality often used in postlaminectomy patients with refractory chronic low back pain. A combination of intrathecal bupivacaine with an opioid is often used.… read more here.
Keywords: low dose; back pain; hydromorphone; bupivacaine ... See more keywords
Morphine and Hydromorphone Effects, Side Effects and Variability - a Crossover Study in Human Volunteers.
Sign Up to like & getrecommendations! Published in 2023 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004567
Abstract: Background: Balancing between opioid analgesia and respiratory depression continues to challenge clinicians in perioperative, emergency department, and other acute care settings. Morphine and hydromorphone are postoperative analgesic standards. Nevertheless, their comparative effects and side effects,… read more here.
Keywords: respiratory depression; hydromorphone; morphine hydromorphone; respiratory ... See more keywords