Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-02996-z
Abstract: PURPOSE Penetration enhancers are necessary to overcome a formidable barrier function of the stratum corneum in the development of topical formulations. Recently, non-lamella liquid crystal (NLLC)-forming lipids such as glycerol monooleate and phytantriol (PHY) are… read more here.
Keywords: hydrophilic drug; permeation; mge; skin permeation ... See more keywords
Influence of the ethanol/dichloromethane ratio on the preparation of microsponges composed of ethylcellulose and Eudragit or HPMCphthalate for hydrophilic drug delivery
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.112633
Abstract: Abstract Microsponges (MS) have shown great potential for the incorporation of relatively higher amounts of drugs. This is due to the presence of both surface pores and interconnected channels that provide a greater contact area… read more here.
Keywords: ethylcellulose eudragit; hydrophilic drug; ethanol dichloromethane; delivery ... See more keywords
Selecting Counterions to Improve Ionized Hydrophilic Drug Encapsulation in Polymeric Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00855
Abstract: Hydrophobic ion pairing (HIP) can successfully increase the drug loading and control the release kinetics of ionizable hydrophilic drugs, addressing challenges that prevent these molecules from reaching the clinic. Nevertheless, polymeric nanoparticle (PNP) formulation development… read more here.
Keywords: pamoic acid; counterions improve; hydrophilic drug; drug ... See more keywords
Poly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride
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DOI: 10.1039/d2ra02845j
Abstract: Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized… read more here.
Keywords: solid lipid; polymer; containing solid; hydrophilic drug ... See more keywords