Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14‐Residue‐Long de novo AMPs
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DOI: 10.1002/cmdc.202000550
Abstract: Herein we report the efficacy and toxicity of three de novo designed cationic antimicrobial peptides (AMPs) LL‐14, VV‐14 and ββ‐14, where side chains of the hydrophobic amino acids were reduced gradually. The AMPs showed broad‐spectrum… read more here.
Keywords: side chains; antimicrobial activity; toxicity; hydrophobic amino ... See more keywords
Tuning the self-assembled nanostructures of ultra-short bola peptides via side chain variations of the hydrophobic amino acids
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DOI: 10.1016/j.molliq.2020.113765
Abstract: Abstract The structure of amino acids in peptides significantly affect the supramolecular architecture. Even small changes in the peptide molecular structure can have dramatic impact on the morphology of the assemblies. Herein, we demonstrate that… read more here.
Keywords: amino acids; hydrophobic amino; aggregate morphology; self ... See more keywords
Water-Soluble Blue Fluorescent Nonconjugated Polymer Dots from Hyaluronic Acid and Hydrophobic Amino Acids
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DOI: 10.1021/acsomega.1c01343
Abstract: Fluorescent polymers have been increasingly investigated to improve their water solubility and biocompatibility to enhance their performance in drug delivery and theranostic applications. However, the environmentally friendly synthesis and dual functionality of such systems remain… read more here.
Keywords: amino acids; water; fluorescent; blue fluorescent ... See more keywords
A Shift in Aggregation Avoidance Strategy Marks a Long-Term Direction to Protein Evolution
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DOI: 10.1534/genetics.118.301719
Abstract: The current consensus among biologists is that evolution does not have a direction. Here, Foy et al. compare recently-born gene families to genes that are chronologically “more evolved,” finding a striking directionality in the evolution...… read more here.
Keywords: protein; aggregation; direction; amino acids ... See more keywords