Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-coupled Receptor during Membrane Approach.
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DOI: 10.1021/acs.biochem.0c00061
Abstract: When lipid mediators bind to G-protein-coupled receptors (GPCRs), the ligand first enters the lipid bilayer, then diffuses laterally in the cell membrane to make hydrophobic contact with the receptor protein, and finally enters the receptor's… read more here.
Keywords: contact point; surface; hydrophobic contact; receptor ... See more keywords