Efficiency encapsulation of FK506 with new dual self-assembly multi-hydrophobic-core nanoparticles for preventing keratoplasty rejection.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203242
Abstract: Nanoparticles self-assembled by amphiphilic co-polymers for loading hydrophobic molecules have been intensively investigated. However, their hydrophobic molecule-loading capacity is low due to the limitation of hydrophobic groups in these co-polymers. In this regard, new lysine… read more here.
Keywords: fk506; multi hydrophobic; hydrophobic core; core nanoparticles ... See more keywords
Structural Basis for the Dissociation of Alpha-Synuclein Fibrils Triggered by Pressure Perturbation of the Hydrophobic Core
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.985
Abstract: Parkinson's disease is a neurological disease in which aggregated forms of the alpha-synuclein (alpha-syn) protein are found. We used high hydrostatic pressure (HHP) coupled with NMR spectroscopy to study the structure and dynamics of alpha-syn… read more here.
Keywords: hydrophobic core; spectroscopy; dissociation; pressure ... See more keywords
Preparation, characterization and antioxidant properties of curcumin encapsulated chitosan/lignosulfonate micelles.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.119080
Abstract: In this work, chitosan/lignosulfonate composite micelles (CS-LS) were successfully prepared through polyelectrolyte self-assembly. Curcumin was encapsulated in CS-LS to obtain CUR-CS-LS. The results showed that the average diameter of CS-LS and CUR-CS-LS were 239 nm and… read more here.
Keywords: chitosan lignosulfonate; characterization antioxidant; preparation characterization; hydrophobic core ... See more keywords
Determining protein similarity by comparing hydrophobic core structure
Sign Up to like & getrecommendations! Published in 2017 at "Heliyon"
DOI: 10.1016/j.heliyon.2017.e00235
Abstract: Formal assessment of structural similarity is − next to protein structure prediction − arguably the most important unsolved problem in proteomics. In this paper we propose a similarity criterion based on commonalities between the proteins’… read more here.
Keywords: hydrophobic core; similarity; determining protein; protein similarity ... See more keywords
Encapsulation of Graphene in the Hydrophobic Core of a Lipid Bilayer
Sign Up to like & getrecommendations! Published in 2020 at "Langmuir"
DOI: 10.1021/acs.langmuir.0c01691
Abstract: Theoretical simulations have predicted that a lipid bilayer forms a stable superstructure when a sheet of graphene is inserted in its hydrophobic core. We experimentally produced for the first time a lipid–graphene–lipid assembly by combining… read more here.
Keywords: hydrophobic core; lipid bilayer; graphene; core lipid ... See more keywords
Atomic insights into the effects of pathological mutants through the disruption of hydrophobic core in the prion protein
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55661-2
Abstract: Destabilization of prion protein induces a conformational change from normal prion protein (PrPC) to abnormal prion protein (PrPSC). Hydrophobic interaction is the main driving force for protein folding, and critically affects the stability and solvability.… read more here.
Keywords: pathological mutants; hydrophobic core; prion protein;
A dynamic hydrophobic core orchestrates allostery in protein kinases
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1600663
Abstract: The synchronized motions of inner core residues allosterically modulate the activity of the protein kinase A catalytic subunit. Eukaryotic protein kinases (EPKs) constitute a class of allosteric switches that mediate a myriad of signaling events.… read more here.
Keywords: protein; hydrophobic core; core orchestrates; protein kinases ... See more keywords
Editorial: From the hydrophobic core to the globular-disorder interface: New challenges and insights into protein design
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1151676
Abstract: Department of Microbiology, Asutosh College, University of Calcutta, Kolkata, India, National Library of Medicine, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, United States, Department of Biostatistics, School of Public Health, Cheeloo… read more here.
Keywords: editorial hydrophobic; globular disorder; hydrophobic core; core globular ... See more keywords