Block copolymers containing dextran and deoxycholic acid polyesters. Synthesis, self-assembly and hydrophobic drug encapsulation.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115118
Abstract: New biocompatible amphiphilic block copolymers were prepared using two natural compounds as starting materials, a polysaccharide (dextran) and a bile acid (deoxycholic acid). The copolymers were synthesized by dipolar 1,3-cycloaddition reaction between dextran with azide… read more here.
Keywords: microscopy; block copolymers; encapsulation; hydrophobic drug ... See more keywords
Design and performance of a poly(vinyl alcohol)/silk fibroin enzymatically crosslinked semi-interpenetrating hydrogel for a potential hydrophobic drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra09344c
Abstract: Enzymatically cross-linked PVA/SF semi-IPN hydrogels with tunable pore structure have potential applications in sustained release of hydrophobic drug. read more here.
Keywords: design performance; performance poly; drug; vinyl alcohol ... See more keywords
DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc05763h
Abstract: We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against… read more here.
Keywords: cytotoxicity; drug patterns; dna framework; framework carriers ... See more keywords
Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072178
Abstract: Polyion complex (PIC) micelles have gained an increasing interest, mainly as promising nano-vehicles for the delivery of various hydrophilic charged (macro)molecules such as DNA or drugs to the body. The aim of the present study… read more here.
Keywords: pic micelles; drug; hydrophobic drug; polyion complex ... See more keywords
Cyclodextrin-Calcium Carbonate Micro- to Nano-Particles: Targeting Vaterite Form and Hydrophobic Drug Loading/Release
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020653
Abstract: Tailor-made and designed micro- and nanocarriers can bring significant benefits over their traditional macroscopic counterparts in drug delivery applications. For the successful loading and subsequent release of bioactive compounds, carriers should present a high loading… read more here.
Keywords: release; micro nano; cyclodextrin calcium; drug ... See more keywords