Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202102004
Abstract: A biocompatible and modifiable protein nanocarrier is a promising candidate for tumor targeted drug delivery. However, it is challenging to effectively load hydrophobic drugs, not to mention to upload both hydrophilic and hydrophobic drugs on… read more here.
Keywords: hydrophobic drugs; protein nanocage; pncage; drug ... See more keywords
"Click" hyaluronan based nanohydrogels as multifunctionalizable carriers for hydrophobic drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.07.003
Abstract: Highly hydrophilic and biocompatible nanocarriers based on polysaccharide hydrogels (nanohydrogels, NHs) were shown to be promising systems for drug delivery applications. Following the idea of these emerging drug carriers, the aim of the present work… read more here.
Keywords: click hyaluronan; hydrophobic drugs; nanohydrogels multifunctionalizable; hyaluronan based ... See more keywords
Engineering and delivery of nanocolloids of hydrophobic drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in colloid and interface science"
DOI: 10.1016/j.cis.2017.04.008
Abstract: A lot of efforts have been devoted to engineering the delivery of hydrophobic drugs due to the high demand of chemotherapy against cancer. While early developed liposomes and polymeric nanoparticles did not meet the requirements… read more here.
Keywords: engineering; delivery; hydrophobic drugs; drug ... See more keywords
In situ supersaturable polyhydrogels: A feasible modification of the conventional hydrogels for the enhanced delivery of stomach specific hydrophobic drugs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101744
Abstract: Abstract In situ supersaturable polyhydrogels are a promising modification of traditional in situ gels to incorporate hydrophobic drugs and specifically deliver them to the stomach for management of gastric cancers and ulcers. This work emphases… read more here.
Keywords: hydrophobic drugs; supersaturable polyhydrogels; stomach; modification ... See more keywords
Driving co-precipitation of hydrophobic drugs in water by conjugating alkyl chains
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102816
Abstract: Abstract Co-precipitated nanoaggregates (NAs) of small-molecule hydrophobic drugs have been widely used as carrier-free drug co-delivery systems, but how to construct stable NAs for potential co-delivery of combination drugs has been remaining unclear. Herein, we… read more here.
Keywords: alkyl chains; drug; alkyl; delivery ... See more keywords
pH-Responsive self-assembly of cationic surfactants with a star-shaped tetra-carboxylate acid and the solubilization of hydrophobic drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Soft matter"
DOI: 10.1039/c7sm01940h
Abstract: This work involved the construction of pH-responsive self-assembly systems from a pH-sensitive four-arm carboxylate acid (4EOCOOH) and either the cationic single chain surfactant dodecyl trimethyl ammonium bromide (DTAB) or the cationic gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide)… read more here.
Keywords: self assembly; carboxylate acid; hydrophobic drugs; solubilization ... See more keywords
Magnetically targeted co-delivery of hydrophilic and hydrophobic drugs with hollow mesoporous ferrite nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra02343c
Abstract: A magnetically targeted drug delivery system (DDS) is developed to solve the delivery problem of hydrophobic drugs by using hollow mesoporous ferrite nanoparticles (HMFNs). The HMFNs are synthesized by a one-pot hydrothermal method based on… read more here.
Keywords: ferrite nanoparticles; delivery; mesoporous ferrite; hydrophobic drugs ... See more keywords
The pH-triggered drug release and simultaneous carrier decomposition of effervescent SiO2–drug–Na2CO3 composite nanoparticles: to improve the antitumor activity of hydrophobic drugs
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra07896d
Abstract: To achieve a better release effect of hydrophobic drugs and spontaneous nanocarrier disintegration by dissolution as well as the CO2 production of Na2CO3 further, improving the therapeutic effect of hydrophobic drugs, and thereby avoiding the… read more here.
Keywords: sio2 drug; drug; hydrophobic drugs; effervescent sio2 ... See more keywords
In situ forming gelatin: Cyclodextrin hydrogels prepared by “click chemistry” to improve the sustained release of hydrophobic drugs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bioactive and Compatible Polymers"
DOI: 10.1177/08839115221098058
Abstract: Injectable hydrogels offer a wide range of attractive benefits in drug delivery applications, such as non-invasive administration, easy drug incorporation and locally controlled release at the target sites. Herein, we designed a simple and efficient… read more here.
Keywords: gelatin cyclodextrin; chemistry; release; drug ... See more keywords
High-Loading Self-Assembling Peptide Nanoparticles as a Lipid-Free Carrier for Hydrophobic General Anesthetics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s315310
Abstract: Purpose Typical hydrophobic amino acids (HAAs) are important motifs for self-assembling peptides (SAPs), but they lead to low water-solubility or compact packing of peptides, limiting their capacity for encapsulating hydrophobic drugs. As an alternative, we… read more here.
Keywords: lipid free; self assembling; hydrophobic general; carrier ... See more keywords
A Comparison of Fucoidan Conjugated to Paclitaxel and Curcumin for the Dual Delivery of Cancer Therapeutic Agents.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520617666171121125845
Abstract: BACKGROUND The aim of this study was to develop and compare polymeric micelles of fucoidan, a sulfated polysaccharide, and hydrophobic drugs such as paclitaxel and curcumin. Paclitaxel and curcumin are both known for their medicinal… read more here.
Keywords: curcumin; delivery; hydrophobic drugs; cancer ... See more keywords