Synthesis and evaluation of sulfosuccinate-based surfactants as counterions for hydrophobic ion pairing.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2022.03.013
Abstract: Hydrophobic ion pairing is a promising strategy to raise the lipophilic character of therapeutic peptides and proteins. In past studies, docusate, an all-purpose surfactant with a dialkyl sulfosuccinate structure, showed highest potential as hydrophobic counterion.… read more here.
Keywords: ion pairing; hydrophobic ion; sulfosuccinate; dioleyl sulfosuccinate ... See more keywords
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.019
Abstract: AIM The aim of this study was the formation and characterization of various ion pairs of therapeutic peptides with different surfactants in order to reach a high payload in self-emulsifying drug delivering systems (SEDDS). METHODS… read more here.
Keywords: self emulsifying; zeta potential; hydrophobic ion; drug ... See more keywords
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design
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DOI: 10.1080/10717544.2022.2118399
Abstract: Abstract The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations. Herein, to enhance the oral absorption of insulin (INS), a self-microemulsifying… read more here.
Keywords: ion pairing; hydrophobic ion; drug delivery; oral absorption ... See more keywords
Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2017.1266329
Abstract: ABSTRACT Introduction: Incorporation of anticancer drugs with low lipophilicity in lipid nanocarriers is usually low, which limits the utilization of this strategy in cancer therapy. However, the complexation of these drugs with lipophilic ion pairs… read more here.
Keywords: hydrophobic ion; lipid nanocarriers; ion; cancer ... See more keywords