Evaluation of the roles of hydrophobic residues in the N-terminal region of archaeal trehalase in its folding.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11237-7
Abstract: Thermoplasma trehalase Tvn1315 is predicted to be composed of a β-sandwich domain (BD) and a catalytic domain (CD) based on the structure of the bacterial GH15 family glucoamylase (GA). Tvn1315 as well as Tvn1315 (Δ5),… read more here.
Keywords: recovered soluble; terminal region; hydrophobic region; hydrophobic residues ... See more keywords
Effects of Hydrophobic Residues on the Intracellular Self-Assembly of De Novo Designed Peptide Tags and Their Orthogonality.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00058
Abstract: Protein assemblies forming nano- to micro-sized structures underlie versatile biological events in living systems. For mimicking and engineering these protein assemblies through a bottom-up approach, self-assembling peptides (SAPs) that form nanofibril structures via β-sheets serve… read more here.
Keywords: self assembly; hydrophobic residues; peptide; intracellular self ... See more keywords
Leucine 232 and hydrophobic residues at the ribosomal P stalk binding site are critical for biological activity of ricin
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20192022
Abstract: Abstract Ricin interacts with the ribosomal P stalk to cleave a conserved adenine from the α-sarcin/ricin loop (SRL) of the rRNA. Ricin toxin A chain (RTA) uses Arg235 as the most critical arginine for binding… read more here.
Keywords: stalk; activity; ribosomal stalk; rta ... See more keywords
The C2A domain of synaptotagmin is an essential component of the calcium sensor for synaptic transmission
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0228348
Abstract: The synaptic vesicle protein, synaptotagmin, is the principle Ca2+ sensor for synaptic transmission. Ca2+ influx into active nerve terminals is translated into neurotransmitter release by Ca2+ binding to synaptotagmin’s tandem C2 domains, triggering the fast,… read more here.
Keywords: synaptic transmission; c2a domain; hydrophobic residues; c2a ... See more keywords
YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071611
Abstract: Simple Summary YY1 regulates various cancer-related genes and activates key oncoproteins. In this study, we discovered that the oncoprotein binding (OPB) domain of YY1 is both necessary and stimulatory to its oligomerization. The hydrophobic residues,… read more here.
Keywords: oligomerization; opb domain; yy1; hydrophobic residues ... See more keywords
Effects of Residual Composition and Distribution on the Structural Characteristics of the Protein
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214263
Abstract: The effect of ratio and consecutive number of hydrophobic residues in the repeating unit of protein chains was investigated by MD simulation. The modified off-lattice HNP model was applied in this study. The protein chains… read more here.
Keywords: structure; effects residual; hydrophobic residues; distribution ... See more keywords