Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles.
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DOI: 10.1016/j.actbio.2019.11.022
Abstract: Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue penetration and efficient drug delivery, their poor stability and intracellular trafficking significantly hinders their use as potent small-sized LNPs. It has been… read more here.
Keywords: cationic lipids; hydrophobic scaffolds; small sized; sensitive cationic ... See more keywords