Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02273
Abstract: Recent advances in targeted protein degradation (TPD) have propelled it to the forefront of small molecular drug discovery. Among these, hydrophobic tagging (HyT) strategies have garnered significant interest. Carbon-based hydrophobic tags have been recognized as… read more here.
Keywords: based hydrophobic; degradation; hydrophobic tags; silicon based ... See more keywords
Hydrophobic Tags for Highly Efficient Light-Activated Protein Release.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00140
Abstract: We have previously described the photoactivated depot (PAD) approach for the light-stimulated release of therapeutic proteins such as insulin. The aim of this method is to release insulin from a shallow dermal depot in response… read more here.
Keywords: insulin; hydrophobic tags; tags highly; polymer ... See more keywords
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00500.s002
Abstract: The onset of neurodegenerative disorders (NDs), such as Alzheimer's disease, is associated with the accumulation of aggregates of misfolded proteins. We previously showed that chemical knockdown of ND-related aggregation-prone proteins can be achieved by proteolysis… read more here.
Keywords: like properties; hydrophobic tags; drug like; mutant huntingtin ... See more keywords