Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
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DOI: 10.1093/nar/gky1232
Abstract: Abstract Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small interfering RNAs (siRNAs). However,… read more here.
Keywords: hydrophobicity drives; lipid transport; hydrophobicity; lipid sirnas ... See more keywords