Synthesis of 1,2,4-Oxadiazolines through Deoxygenative Cyclization of N-Vinyl-α,β-Unsaturated Nitrones with in Situ Generated Nitrile Oxides from Hydroxamoyl Chlorides.
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DOI: 10.1021/acs.orglett.2c04121
Abstract: A variety of 1,2,4-oxadiazoline derivatives were synthesized in moderate to good yields through a deoxygenative cyclization cascade reaction of N-vinyl-α,β-unsaturated nitrones and hydroxamoyl chlorides. Mechanistic studies revealed that the reaction underwent double additions of nitrile… read more here.
Keywords: deoxygenative cyclization; hydroxamoyl chlorides; unsaturated nitrones; vinyl unsaturated ... See more keywords