Stream-lined synthesis of 3-hydroxy-β-lactams: Norrish-Yang type II photocyclizations of β-ketoformamides
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DOI: 10.1016/j.tet.2018.04.040
Abstract: Abstract A photochemical approach to 3-phenyl-3-hydroxy-β-lactams (3-HβLs) is reported. Irradiation of aryl-β-ketoformamides with a UV light band centered at 300 nm provides the corresponding 3-aryl-3-HβLs with good conversion. The scope of the photocyclization is explored with… read more here.
Keywords: norrish yang; stream lined; yang type; hydroxy lactams ... See more keywords
Chemoenzymatic Approach toward the Synthesis of 3-O-(α/β)-Glucosylated 3-Hydroxy-β-lactams
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DOI: 10.1021/acsomega.8b01969
Abstract: Glycosylation significantly alters the biological and physicochemical properties of small molecules. β-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In this framework, the… read more here.
Keywords: hydroxy lactams; toward synthesis; approach toward; synthesis ... See more keywords