Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112070
Abstract: Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made.… read more here.
Keywords: hydroxy methoxyphenyl; potent analgesic; methyl hydroxy; dimethylamino methyl ... See more keywords
Previously undescribed pyridyl-steroidal glycoalkaloids and 23S,26R-hydroxylated spirostanoid saponin from the fruits of Solanum violaceum ortega and their bioactivities.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112656
Abstract: Three previously undescribed pyridyl-steroidal glycoalkaloids, solanindiosides A‒C, one rare 23S,26R-hydroxylated spirostanoid saponin, and two steroidal alkaloid aglycones, solanindins A and B, derived from the acid hydrolysis of solanindiosides A‒C, were isolated from the fruits of… read more here.
Keywords: hydroxy methoxyphenyl; pyridyl steroidal; undescribed pyridyl; methoxy ... See more keywords
Quantitative Antioxidant Profiling Throughout Beer Brewing Followed by Discovery and Isolation of Precursors from Barley (Hordeum vulgare L.)
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.4c00998
Abstract: The application of high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) revealed the origin and evolution of antioxidants during the brewing process of hopped and unhopped reference beer. As tachioside (3-methoxy-4-hydroxyphenyl-β-d-glucopyranoside), arbutin (4-hydroxyphenyl-β-d-glucopyranoside), and hordatines clearly increased during… read more here.
Keywords: glucopyranosyl glucopyranoside; barley; hydroxy methoxyphenyl; beer ... See more keywords
First total synthesis of 7-(3,4-dimethoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)heptan-3-one (a diarylheptanoid).
Sign Up to like & getrecommendations! Published in 2025 at "Natural product research"
DOI: 10.1080/14786419.2025.2522812
Abstract: Herein, we demonstrate the first total synthesis of a natural product, 7-(3,4-dimethoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)heptan-3-one using the commercially available starting materials 1,2- dimethoxy benzene and vanillin with 20% overall yield in 15 steps. The present synthesis employs classical… read more here.
Keywords: dimethoxyphenyl hydroxy; methoxyphenyl heptan; hydroxy methoxyphenyl; synthesis ... See more keywords
In silico screening of ethyl 4-[(E)-(2-hydroxy-4-methoxyphenyl)methyleneamino]benzoate and some of its derivatives for their NLO activities using DFT
Sign Up to like & getrecommendations! Published in 2023 at "Royal Society Open Science"
DOI: 10.1098/rsos.220430
Abstract: The nonlinear optical (NLO) properties of ethyl 4-[(E)-(2-hydroxy-4-methoxyphenyl)methyleneamino]benzoate (EMAB) and some of its derivatives are investigated herein using the density functional theory (DFT) and time-dependent (TD)-DFT methods. The density functionals B3LYP, CAM-B3LYP, M06-2X and ωB97XD,… read more here.
Keywords: nlo activities; methoxyphenyl methyleneamino; dft; hydroxy methoxyphenyl ... See more keywords
3-{(E)-[4-(4-Hydroxy-3-methoxyphenyl)butan-2-ylidene]amino}-1-phenylurea: crystal structure and Hirshfeld surface analysis
Sign Up to like & getrecommendations! Published in 2018 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017017273
Abstract: The disubstituted urea molecule has a twisted conformation for each of the two molecules comprising the asymmetric unit. Intramolecular amine-N—H⋯N(imine) and hydroxy-O—H⋯O(methoxy) hydrogen bonds are noted. In the molecular packing, amide-N—H⋯O(amide), hydroxyl-O—H⋯N(imine) and phenylamine-N—H⋯O(methoxy) hydrogen… read more here.
Keywords: hydroxy methoxyphenyl; butan ylidene; methoxyphenyl butan; phenylurea crystal ... See more keywords
Spectroscopic Characterization and Biological Activity of Hesperetin Schiff Bases and Their Cu(II) Complexes
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010761
Abstract: The three Schiff base ligands, derivatives of hesperetin, HHSB (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]isonicotinohydrazide), HIN (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]benzhydrazide) and HTSC (N-[2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene]thiosemicarbazide) and their copper complexes, CuHHSB, CuHIN, and CuHTSC were designed, synthesized and analyzed in terms of their spectral characterization and… read more here.
Keywords: schiff bases; dihydro dihydroxy; dihydroxy hydroxy; hydroxy methoxyphenyl ... See more keywords